Contact RCB Admin Directly

Do Follow Us!

Follow Us on Twitter Find Us on Facebook Join Us On Social Media.-
Subscribe to Our YouTube Channel
SCROLL DOWN TO READ MORE RECENT ARTICLES
"Our Articles are just Unpredictable, so stay tuned"

TO PRINT ANY ARTICLE ON THIS SITE, GOTO THE COMMENT SECTION AND CLICK THE PRINT ICON.

Wednesday, March 25, 2020

Nipping Cancer in the bud using Phytochemicals

Written by: Emmanuel Okezie and Muoka Chibuzor


According to the World Health Organisation (WHO), Cancer as the second leading cause of death globally has held human health to ransom. In a quest for a cure, man delves into pharmacognosy where he discovered phytochemicals which are chemical substances of plant origin that exerts healing effects.

Cancer is a disease condition characterized by the dysregulation of growth control mechanisms within a cell, and the role of phytochemicals as "disciplinarians" in arresting the suddenly turned cancerous cells has been supported by concrete research evidence.

Phytochemicals had earlier been known to protect plants against harsh environmental conditions as they cannot move when they are stressed. Thus their role in supporting man may not be farfetched.

The growing health worries of cancer has increased worldwide, despite global relentless efforts from scientists which aimed at decreasing the mortality rate. In 2012 alone, the Global Cancer statistical study revealed about 8.2 million deaths from cancer.

In a study published in Avicenna Journal of Phytomedicine in 2015, two researchers from Mashhad University of Medical Sciences, Iran; used different scientific published evidence from clinical trials to reveal the anticancer potency of phytochemicals.

The authors have reported that modern treatment options e.g., radiotherapy, surgical operations and the use of chemotherapy often evoked strong undesired adverse effects. Thus the strong need for natural phytochemicals with potent anticancer properties.

The authors stressed that current synthetic drugs not only attack cancer cells but also exerts stress on normal cells. Thereby causing cell injury that leads to irreparable cell death. Patients who take chemotherapeutic drugs may present with impaired hematopoiesis features, frequent hair loss (alopecia), and cardiovascular diseases. Cancer patients may even die due to these adverse effects.

To augment for the consequences of chemotherapy, researchers presented phytochemicals as an alternative saviour. In their reports, they revealed that plant-based bioactive substances can be used in the treatment of cancer due to their low side-effects in contrast to the synthetic cancer-treating drugs e.g., antimetabolites used in chemotherapy.

Research began at the preclinical stage with the use of phytochemicals as a cancer remedy in experimental animals. With positive results, further studies and clinical trials affirmed that phytochemical can beneficially influence the cell growth cycle.

Today, plant-derived compounds such as vinca alkaloids and podophyllotoxin have gained popularity in the treatment of cancer patients. These compounds have been found as promising active ingredients present in most chemotherapies.

In this report, phytochemicals present in curcumin, Allium sativum (garlic), green tea, Panax ginseng, Viscum album, camptothecin and resveratrol have been clinically tested in the treatment of a number of cancers such as colorectal, pancreatic, adenomas, prostate, oesophageal, uterine, ovarian and lung cancers.

Natural foods contain Anti-oxidants that fight
against Cancer initiating substances

They showed that cancer patients who were administered a certain dosage of these therapeutic phytochemicals over a given period of time had increased survival time, improved activity of the natural killer cells decreased the spreading of cancer cells (metastasis) and elevated levels of their immune system.

The researchers uncovered that the anticancer effects of these phytochemicals were primarily because they had antioxidant effects; which can reduce the activities of free radicals that accumulate and cause stress to cells, thereby making them cancerous. Other mechanisms of action include their ability to inhibit unregulated cell cycle, initiate programmed cell death (apoptosis) and inhibit the channels through which cancer cells can get blood supply and nutrients.


Notwithstanding the credence of phytochemicals nipping cancer to the bud, the authors have suggested that further studies should be done to help reduce information bias, uncover hidden drug interactions and possible contraindications. They stated the importance of most of these reported clinical trials were done with small groups within a short time-frame.



Do, not Miss Anything!!! Subscribe to our Email Updates to get the latest Articles in your Email instantly.
Enter your email below, submit and check your inbox right now.   Delivered by FeedBurner
Share this Post Share to Facebook Share to Twitter Email This Pin This

No comments:

Post a comment

RULES FOR COMMENTERS: - 11/30/2018

1) Its good to say your mind about what you have read. Please do make ethical comment(s).

2) COMMENTS WITH UNACCEPTABLE LINKS (URLs) WILL BE DELETED IMMEDIATELY BY THE COMMENT MODERATOR.

If you won't abide by the rules please do not comment.
Thanks.

Recent Comments

Back to Top